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Table of Contents
LETTER TO EDITOR
Year : 2022  |  Volume : 21  |  Issue : 2  |  Page : 202

Evaluation of Some Biomarkers in Diagnosis of Bacterial Bloodstream Infection in Children


Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Submission24-Dec-2021
Date of Decision10-Jul-2022
Date of Acceptance13-Jul-2022
Date of Web Publication2-Jan-2023

Correspondence Address:
Prof. Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, P.O. Box 55302, Baghdad Post Office, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mj.mj_42_21

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How to cite this article:
Al-Mendalawi MD, Al-Khalidi MJ. Evaluation of Some Biomarkers in Diagnosis of Bacterial Bloodstream Infection in Children. Mustansiriya Med J 2022;21:202

How to cite this URL:
Al-Mendalawi MD, Al-Khalidi MJ. Evaluation of Some Biomarkers in Diagnosis of Bacterial Bloodstream Infection in Children. Mustansiriya Med J [serial online] 2022 [cited 2023 Feb 8];21:202. Available from: https://www.mmjonweb.org/text.asp?2022/21/2/202/366631

Dear Editor,

In the July–December 2021 issue of the Mustansiriya Medical Journal, Abood et al.[1] assessed the role of C-reactive protein (CRP) and procalcitonin (PCT) as biomarkers of pediatric sepsis (PS). They found that the mean levels of serum CRP and PCT in the Gram-negative and Gram-positive groups differed significantly from the control group.[1] They concluded that the utilization of these biomarkers as diagnostic tests might help in the early diagnosis of PS.[1] Indeed, serum levels of CRP and PCT are not only reliable in the diagnosis of PS but also in predicting the overwhelming progression of the septic patient.[2],[3] A concern exists considering the clinical implication of measuring serum CRP and PCT as there is a need to utilize optimal cutoff levels of CRP and PCT with a regard to various pediatric age groups. Importantly, these cutoff values have been constructed for certain pediatric populations to be employed in the researches centers and clinical practice.[4],[5] Regrettably, no similar cutoff levels are yet present in Iraq. The study by Abood et al.[1] truly triggers the need to formulate Iraqi pediatric cutoff values of CRP and PCT. Meanwhile, it would be prudent to study the diagnostic value of CRP versus PCT in predicting PS in Iraq.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Abood RM, Ashoor ZF, Al Saadi YI. Evaluation of some biomarkers in diagnosis of bacterial bloodstream infection in children. Mustansiriya Med J 2021;20:62-5.  Back to cited text no. 1
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2.
Huang X, Wang J, Li H. Diagnostic and prognostic values of serum procalcitonin and C-reactive protein in patients of bacterial sepsis. Zhonghua Yi Xue Za Zhi 2014;94:2106-9.  Back to cited text no. 2
    
3.
Szederjesi J, Almasy E, Lazar A, Huțanu A, Badea I, Georgescu A. An evaluation of serum procalcitonin and C-reactive protein levels as diagnostic and prognostic biomarkers of severe sepsis. J Crit Care Med (Targu Mures) 2015;1:147-53.  Back to cited text no. 3
    
4.
Aydemir C, Aydemir H, Kokturk F, Kulah C, Mungan AG. The cut-off levels of procalcitonin and C-reactive protein and the kinetics of mean platelet volume in preterm neonates with sepsis. BMC Pediatr 2018;18:253.  Back to cited text no. 4
    
5.
Joyce CM, Deasy S, Abu H, Lim YY, O'Shea PM, O'Donoghue K. Reference values for C-reactive protein and procalcitonin at term pregnancy and in the early postnatal period. Ann Clin Biochem 2021;58:452-60.  Back to cited text no. 5
    




 

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