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Year : 2021  |  Volume : 20  |  Issue : 2  |  Page : 66-70

The role of insulin level on the biofilm-forming capacity in diabetes-related urinary tract infection

1 Department of Microbiology, College of Medicine, Mustansiriya University, Baghdad, Iraq
2 Ministry of Health, Central Public Health Laboratory, Baghdad, Iraq

Correspondence Address:
Mrs. Wasan Ghanim Abed
Department of Microbiology, College of Medicine, Mustansiriya University, Baghdad
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mj.mj_12_21

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Background: Type 2 diabetes mellitus (T2DM) is more prone to get infections and the most common infection is urinary tract infection (UTI), most of the causative agents are related to biofilms, biofilm-forming capacity affected by host factors such as glucose and others. Aims: The objective of this research was to see how insulin affects the biofilm-forming capacity that most common pathogens associated with diabetic patients in different isolates. Materials and Methods: The objective was investigated by comparing the amounts of serum insulin in UTI patients to those without UTI whether the patients with T2DM or nondiabetic. The study was conducted on 40 T2DM patients divided into 20 patients with UTI and 20 without UTI, and 40 nondiabetic control subjects 20 with UTI and 20 patients without UTI. Serum insulin levels were detected by using enzyme-linked immunosorbent assay kit. Results: The mean concentration of serum insulin was a highly significant increase in T2DM in comparison to the nondiabetic control group. Pseudomonas auroginosa was the strongest biofilm producer isolate. Conclusion: In conclusion, insulin's direct effect was elevated the capability of biofilm formation. This contributes to a better knowledge of the causes of frequent bacterial infections in diabetics.

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