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ORIGINAL ARTICLE
Year : 2021  |  Volume : 20  |  Issue : 2  |  Page : 45-48

In vitro assessment of antimicrobial susceptibility patterns in positive blood cultures of 22 neonates with neonatal sepsis in a children's hospital in Baghdad


1 Department of Pharmacology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
2 Department of Neonatology, Al-Elwiyah Pediatric Teaching Hospital, Baghdad, Iraq

Correspondence Address:
Saad Badai Nashtar
Department of Pharmacology, University of Baghdad, Al-Kindy College of Medicine, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mj.mj_7_21

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Introduction: neonatal sepsis (NS) is a serious disease in neonatology responsible for the higher percentage of neonatal deaths. It is a microbial disease caused by various types of bacterial and nonbacterial pathogens. Objectives: The objective is to determine the causative bacterial pathogens of NS for the specified period and their susceptibility toward the available antimicrobial drugs. Patients and Methods: Blood cultures of 67 neonates with clinical picture of NS were assessed for antimicrobial sensitivity. Results: Forty three cultures (64.2%) were negative, 4 cultures (5.9%) revealed Candida spp. and 20 (29.9%) cultures were positive. Gram-negative bacteria Klebsiella was the predominant pathogen causing NS (45.45%) followed be Gram-positive Staphylococcus aureus (18.2%). Vancomycin, ciprofloxacin, and amikacin were the most effective antimicrobials against Gram-positive isolates while imipenem was the most effective against Gram-negative bacteria. Discussion: klebsiella was the predominant microbe in NS in many studies, other pathogens were variable between countries. Vancomycin and imipenem approved their excellent effects reported in many others studies while penicillin approved high bacterial resistance recorded previously. Conclusion: Gram-negative bacteria were predominant and more resistant to the tested antimicrobials. Imipenem, vancomycin, ciprofloxacin were the best effective according to the isolated microbes.


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