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Year : 2019  |  Volume : 18  |  Issue : 1  |  Page : 43-46

The association of serum copper with ceruloplasmin and zinc with folic acid levels in recurrent pregnancy loss in Iraqi Women

1 Department of Chemistry and Biochemistry, College of Medicine, Al-Mustansiryia University, Baghdad, Iraq
2 Department of Obstetrics and Gynaecology, College of Medicine, Al-Mustansiryia University, Baghdad, Iraq

Correspondence Address:
Ms. Olaa Riad Kadim
Department of Chemistry and Biochemistry, College of Medicine, Al.Mustansiryia University, Baghdad
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJ.MJ_41_18

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Background and Objectives: Recurrent pregnancy loss (RPL) is the most common adverse pregnancy outcome. Micronutrients include minerals and vitamins are essential for normal function, growth, and development. Minerals have important effects on the health of the mother and the fetus. Micronutrient deficiency during pregnancy can lead to obstetric complications and even fetal death. Materials and Methods: A total of 90 pregnant women included in this study were between 7 and 20 weeks of gestation, their age was 18–40 years, and they were divided into three main groups. Patients: Group 1, pregnant women diagnosed with missed miscarriage no = 30; Controls: Group 2, ongoing pregnancy no = 30; and Group 3, nonpregnant women no = 30. Serum copper (Cu) and zinc (Zn) were determined using flame atomic absorption spectrometry. While the serum ceruloplasmin (CP) was measured by immunoturbidimetric assay and folic acid (FA) by enzyme-linked immune sorbent assay. Results: Serum Cu and CP were significantly higher in the women with RPL compared with healthy groups. Moreover, the levels of Zn were significantly lower in in women with RPL compared with healthy control groups, and the result of serum FA was showed that there no significant variation in patients with RPL compared with control groups. Conclusions: The study showed that the alteration in the trace elements could participate with the RPL.

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